Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

As neuronal differentiation of embryonic stem cells (ESCs) recapitulates embryonic neurogenesis, disturbances of this process may model developmental neurotoxicity (DNT). To identify the relevant steps of in vitro neurodevelopment, we implemented a differentiation protocol yielding neurons with desi...

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Detalhes bibliográficos
Main Authors: Zimmer, B, Kuegler, P B, Baudis, B, Genewsky, A, Tanavde, V, Koh, W, Tan, B, Waldmann, T, Kadereit, S, Leist, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131999/
https://ncbi.nlm.nih.gov/pubmed/20865013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.109
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