Clearance and Toxicity of Recombinant Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (r-metHu GDNF) Following Acute Convection-Enhanced Delivery into the Striatum

BACKGROUND: Despite promising early results, clinical trials involving the continuous delivery of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) into the putamen for the treatment of Parkinson's disease have shown evidence of poor distribution and toxicity...

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Main Authors: Taylor, Hannah, Barua, Neil, Bienemann, Alison, Wyatt, Marcella, Castrique, Emma, Foster, Rebecca, Luz, Matthias, Fibiger, Christian, Mohr, Erich, Gill, Steven
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603959/
https://ncbi.nlm.nih.gov/pubmed/23526931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056186
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