Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model

BACKGROUND: Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for intracerebral pharmacological therapy. By establishing a pressure gradient at the tip of the catheter, drugs can be delivered in uniform...

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Detalhes bibliográficos
Main Authors: Barua, Neil U, Bienemann, Alison S, Hesketh, Shirley, Wyatt, Marcella J, Castrique, Emma, Love, Seth, Gill, Steven S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274474/
https://ncbi.nlm.nih.gov/pubmed/22264361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-8118-9-2
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