Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice

BACKGROUND: Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isoforms. Genetic variati...

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Detalhes bibliográficos
Main Authors: Scott, William R., Gelegen, Cigdem, Chandarana, Keval, Karra, Efthimia, Yousseif, Ahmed, Amouyal, Chloé, Choudhury, Agharul I., Andreelli, Fabrizio, Withers, Dominic J., Batterham, Rachel L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603916/
https://ncbi.nlm.nih.gov/pubmed/23527188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059407
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