Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance

The effect of peptide tyrosine–tyrosine (PYY) on feeding is well established but currently its role in glucose homeostasis is poorly defined. Here we show in mice, that intraperitoneal (ip) injection of PYY3-36 or Y2R agonist improves nutrient-stimulated glucose tolerance and enhances insulin secret...

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Autori principali: Chandarana, Keval, Gelegen, Cigdem, Irvine, Elaine E., Choudhury, Agharul I., Amouyal, Chloé, Andreelli, Fabrizio, Withers, Dominic J., Batterham, Rachel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773824/
https://ncbi.nlm.nih.gov/pubmed/24049729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2013.03.001
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