Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance

The effect of peptide tyrosine–tyrosine (PYY) on feeding is well established but currently its role in glucose homeostasis is poorly defined. Here we show in mice, that intraperitoneal (ip) injection of PYY3-36 or Y2R agonist improves nutrient-stimulated glucose tolerance and enhances insulin secret...

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Detalhes bibliográficos
Main Authors: Chandarana, Keval, Gelegen, Cigdem, Irvine, Elaine E., Choudhury, Agharul I., Amouyal, Chloé, Andreelli, Fabrizio, Withers, Dominic J., Batterham, Rachel L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773824/
https://ncbi.nlm.nih.gov/pubmed/24049729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2013.03.001
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