Toxoplasma gondii Triggers Phosphorylation and Nuclear Translocation of Dendritic Cell STAT1 while Simultaneously Blocking IFNγ-Induced STAT1 Transcriptional Activity

The protozoan Toxoplasma gondii actively modulates cytokine-induced JAK/STAT signaling pathways to facilitate survival within the host, including blocking IFNγ-mediated STAT1-dependent proinflammatory gene expression. We sought to further characterize inhibition of STAT1 signaling in infected murine...

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Detalhes bibliográficos
Main Authors: Schneider, Anne G., Abi Abdallah, Delbert S., Butcher, Barbara A., Denkers, Eric Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603897/
https://ncbi.nlm.nih.gov/pubmed/23527309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060215
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