STAT1 Is Essential for Antimicrobial Effector Function but Dispensable for Gamma Interferon Production during Toxoplasma gondii Infection

The opportunistic protozoan Toxoplasma gondii is a prototypic Th1-inducing pathogen inducing strong gamma interferon (IFN-γ) cytokine responses that are required to survive infection. Intracellular signaling intermediate STAT1 mediates many effects of IFN-γ and is implicated in activation of T-bet,...

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Bibliographic Details
Main Authors: Gavrilescu, L. Cristina, Butcher, Barbara A., Del Rio, Laura, Taylor, Gregory A., Denkers, Eric Y.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC356043/
https://ncbi.nlm.nih.gov/pubmed/14977926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.3.1257-1264.2004
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