The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance to Toxoplasma gondii Is Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments

IGTP is a member of the 47-kDa family of gamma interferon (IFN-γ)-induced GTPases. We have previously shown that IGTP is critical for host resistance to Toxoplasma gondii infection. In the present study, we demonstrate that T. gondii-induced IGTP expression in vivo and IFN-γ-driven synthesis of the...

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Bibliografiske detaljer
Main Authors: Collazo, Carmen M., Yap, George S., Hieny, Sara, Caspar, Patricia, Feng, Carl G., Taylor, Gregory A., Sher, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC132942/
https://ncbi.nlm.nih.gov/pubmed/12438372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.6933-6939.2002
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