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N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors

Deleted in colorectal cancer (DCC) is a receptor for the axon guidance cues netrin-1 and draxin. The interactions between these guidance cues and DCC play a key role in the development of the nervous system. In the present study, we reveal the crystal structure of the N-terminal four Ig-like domains...

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Библиографические подробности
Главные авторы: Chen, Qiang, Sun, Xiaqin, Zhou, Xiao-hong, Liu, Jin-huan, Wu, Jane, Zhang, Yan, Wang, Jia-huai
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603515/
https://ncbi.nlm.nih.gov/pubmed/23038776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.111278
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