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N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors
Deleted in colorectal cancer (DCC) is a receptor for the axon guidance cues netrin-1 and draxin. The interactions between these guidance cues and DCC play a key role in the development of the nervous system. In the present study, we reveal the crystal structure of the N-terminal four Ig-like domains...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Company of Biologists
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603515/ https://ncbi.nlm.nih.gov/pubmed/23038776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.111278 |
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