A distal phenylalanine clamp in a hydrophobic channel controls the substrate specificity in the quorum-quenching metallo-γ-lactonase (AiiA) from Bacillus thuringiensis

AiiA is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substrate specificity, but shows preference for substrates with long N-acyl substitutions. Previously, crystal structures of AiiA in complex with the ring-opened product N-hexanoyl-l-homoserine revealed binding interac...

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Main Authors: Liu, Ce Feng, Liu, Dali, Momb, Jessica, Thomas, Pei W., Lajoie, Ashley, Petsko, Gregory A., Fast, Walter, Ringe, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603367/
https://ncbi.nlm.nih.gov/pubmed/23387521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400050j
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