Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 1. Product-Bound Structures

[Image: see text] Enzymes capable of hydrolyzing N-acyl-l-homoserine lactones (AHLs) used in some bacterial quorum-sensing pathways are of considerable interest for their ability to block undesirable phenotypes. Most known AHL hydrolases that catalyze ring opening (AHL lactonases) are members of the...

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Detalhes bibliográficos
Main Authors: Liu, Dali, Momb, Jessica, Thomas, Pei W., Moulin, Aaron, Petsko, Gregory A., Fast, Walter, Ringe, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646676/
https://ncbi.nlm.nih.gov/pubmed/18627129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800368y
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