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The quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis exhibits a leaving group thio effect

Lactone-hydrolyzing enzymes derived from some Bacillus species are capable of disrupting quorumsensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling molecules. Despite the promise of these quorum-quenching enzymes as therapeutic and anti-biofouling agents, the r...

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Detalhes bibliográficos
Main Authors: Momb, Jessica, Thomas, Pei W., Breece, Robert M., Tierney, David L., Fast, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526230/
https://ncbi.nlm.nih.gov/pubmed/17073460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061238o
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