Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.

We previously observed that human ADA gene expression, required for the intrathymic maturation of T cells, is controlled by first-intron sequences. Used as a cis activator, the intron generates copy-dependent reporter expression in transgenic thymocytes, and we here dissect its critical determinants...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Aronow, B J, Silbiger, R N, Dusing, M R, Stock, J L, Yager, K L, Potter, S S, Hutton, J J, Wiginton, D A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1508212/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.9.4170-4185.1992
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