Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.

We previously observed that human ADA gene expression, required for the intrathymic maturation of T cells, is controlled by first-intron sequences. Used as a cis activator, the intron generates copy-dependent reporter expression in transgenic thymocytes, and we here dissect its critical determinants...

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Detalhes bibliográficos
Main Authors: Aronow, B J, Silbiger, R N, Dusing, M R, Stock, J L, Yager, K L, Potter, S S, Hutton, J J, Wiginton, D A
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC360321/
https://ncbi.nlm.nih.gov/pubmed/1508212
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