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Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer
Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling v...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602724/ https://ncbi.nlm.nih.gov/pubmed/23519101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2013.00031 |
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