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Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer

Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling v...

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Detalhes bibliográficos
Main Authors: Philippou, Anastassios, Armakolas, Athanasios, Koutsilieris, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602724/
https://ncbi.nlm.nih.gov/pubmed/23519101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2013.00031
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