Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

The present study characterized the TGR5 expression and the signaling pathways coupled to this receptor that mediates the relaxation of gastric smooth muscle. TGR5 was detected in gastric muscle cells by RT-PCR and Western blotting. Treatment of cells with the TGR5-selective ligand oleanolic acid (O...

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Main Authors: Rajagopal, Senthilkumar, Kumar, Divya P., Mahavadi, Sunila, Bhattacharya, Sayak, Zhou, Ruizhe, Corvera, Carlos U., Bunnett, Nigel W., Grider, John R., Murthy, Karnam S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2013
Ábhair:
Neuroregulation and Motility
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602680/
https://ncbi.nlm.nih.gov/pubmed/23275618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00388.2012
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