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Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism

Mast cells regulate intestinal barrier function during disease and homeostasis. Secretion of the mast cell-specific serine protease chymase regulates homeostasis. In the present study, we employ in vitro model systems to delineate the molecular pathways involved in chymase-mediated intestinal epithe...

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Main Authors: Groschwitz, Katherine R., Wu, David, Osterfeld, Heather, Ahrens, Richard, Hogan, Simon P.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602679/
https://ncbi.nlm.nih.gov/pubmed/23306080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00186.2012
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