Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease

The four glycoforms of the cellular prion protein (PrP(C)) variably glycosylated at the two N-linked glycosylation sites are converted into their pathological forms (PrP(Sc)) in most cases of sporadic prion diseases. However, a prominent molecular characteristic of PrP(Sc) in the recently identified...

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Autori principali: Xiao, Xiangzhu, Yuan, Jue, Haïk, Stéphane, Cali, Ignazio, Zhan, Yian, Moudjou, Mohammed, Li, Baiya, Laplanche, Jean-Louis, Laude, Hubert, Langeveld, Jan, Gambetti, Pierluigi, Kitamoto, Tetsuyuki, Kong, Qingzhong, Brandel, Jean-Philippe, Cobb, Brian A., Petersen, Robert B., Zou, Wen-Quan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602448/
https://ncbi.nlm.nih.gov/pubmed/23527023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058786
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