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Two-component covalent inhibitor

Inhibitors that covalently damage proteins or nucleic acids offer great potency, but are difficult to rationally design and suffer from poor specificity. Here we outline a general concept for constructing covalent inhibitors, called the two-component covalent inhibitor (TCCI). The approach takes adv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cornett, Evan M., Gerasimova, Yulia V., Kolpashchikov, Dmitry M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602336/
https://ncbi.nlm.nih.gov/pubmed/23411398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.01.021
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