Fatty Acid Ethyl Esters Induce Intestinal Epithelial Barrier Dysfunction via a Reactive Oxygen Species-Dependent Mechanism in a Three-Dimensional Cell Culture Model

BACKGROUND & AIMS: Evidence is accumulating that ethanol and its oxidative metabolite, acetaldehyde, can disrupt intestinal epithelial integrity, an important factor contributing to ethanol-induced liver injury. However, ethanol can also be metabolized non-oxidatively generating phosphatidyletha...

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Main Authors: Elamin, Elhaseen, Masclee, Ad, Juuti-Uusitalo, Kati, van IJzendoorn, Sven, Troost, Freddy, Pieters, Harm-Jan, Dekker, Jan, Jonkers, Daisy
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602318/
https://ncbi.nlm.nih.gov/pubmed/23526996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058561
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