Effects of Ethanol and Acetaldehyde on Tight Junction Integrity: In Vitro Study in a Three Dimensional Intestinal Epithelial Cell Culture Model

BACKGROUND: Intestinal barrier dysfunction and translocation of endotoxins are involved in the pathogenesis of alcoholic liver disease. Exposure to ethanol and its metabolite, acetaldehyde at relatively high concentrations have been shown to disrupt intestinal epithelial tight junctions in the conve...

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Main Authors: Elamin, Elhaseen, Jonkers, Daisy, Juuti-Uusitalo, Kati, van IJzendoorn, Sven, Troost, Freddy, Duimel, Hans, Broers, Jos, Verheyen, Fons, Dekker, Jan, Masclee, Ad
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339854/
https://ncbi.nlm.nih.gov/pubmed/22563376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035008
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