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Evaluating Risks of Insertional Mutagenesis by DNA Transposons in Gene Therapy

Investigational therapy can be successfully undertaken using viral- and non-viral-mediated ex vivo gene transfer. Indeed, recent clinical trials have established the potential for genetically modified T cells to improve and restore health. Recently the Sleeping Beauty (SB) transposon/transposase sys...

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Hlavní autoři: Hackett, Perry B., Largaespada, David A., Switzer, Kirsten C., Cooper, Laurence J.N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602164/
https://ncbi.nlm.nih.gov/pubmed/23313630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2012.12.005
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