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The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation.

Expression of the human osteocalcin promoter is negatively regulated by glucocorticoids in vivo. In vitro DNase I and exonuclease III footprinting analysis showed binding of purified glucocorticoid receptor in close proximity to and overlapping with the TATA box of the osteocalcin gene. These result...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Strömstedt, P E, Poellinger, L, Gustafsson, J A, Carlstedt-Duke, J
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 1991
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360193/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2038339/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.6.3379
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