The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation.

Expression of the human osteocalcin promoter is negatively regulated by glucocorticoids in vivo. In vitro DNase I and exonuclease III footprinting analysis showed binding of purified glucocorticoid receptor in close proximity to and overlapping with the TATA box of the osteocalcin gene. These result...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Strömstedt, P E, Poellinger, L, Gustafsson, J A, Carlstedt-Duke, J
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1991
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2038339/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.6.3379-3383.1991
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