The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.

The immunosuppressants cyclosporin A, FK506, and rapamycin inhibit growth of unicellular eukaryotic microorganisms and also block activation of T lymphocytes from multicellular eukaryotes. In vitro, these compounds bind and inhibit two different types of peptidyl-prolyl cis-trans isomerases. Cyclosp...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Heitman, J, Koller, A, Kunz, J, Henriquez, R, Schmidt, A, Movva, N R, Hall, M N
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360149/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7687745/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.5010-5019.1993
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