Expression of functionally active sialylated human erythropoietin in plants

Recombinant human erythropoietin (rhEPO), a glycohormone, is one of the leading biopharmaceutical products. The production of rhEPO is currently restricted to mammalian cell expression systems because of rhEPO's highly complex glycosylation pattern, which is a major determinant for drug-efficac...

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Библиографические подробности
Главные авторы: Jez, Jakub, Castilho, Alexandra, Grass, Josephine, Vorauer-Uhl, Karola, Sterovsky, Thomas, Altmann, Friedrich, Steinkellner, Herta
Формат: Artigo
Язык:Inglês
Опубликовано: WILEY-VCH Verlag 2013
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601435/
https://ncbi.nlm.nih.gov/pubmed/23325672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201200363
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