IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques

Intramuscular injection of macaques with an IL-12 expression plasmid (0.1 or 0.4 mg DNA/animal) optimized for high level of expression and delivered using in vivo electroporation, resulted in the detection of systemic IL-12 cytokine in the plasma. Peak levels obtained by day 4–5 post injection were...

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Main Authors: Jalah, Rashmi, Patel, Vainav, Kulkarni, Viraj, Rosati, Margherita, Alicea, Candido, Ganneru, Brunda, von Gegerfelt, Agneta, Huang, Wensheng, Guan, Yongjun, Broderick, Kate E., Sardesai, Niranjan Y., LaBranche, Celia, Montefiori, David C., Pavlakis, George N., Felber, Barbara K.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601136/
https://ncbi.nlm.nih.gov/pubmed/22894956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.21407
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