The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand

BACKGROUND: Heparin cofactor II (HCII) is a circulating protease inhibitor, one which contains an N-terminal acidic extension (HCII 1-75) unique within the serpin superfamily. Deletion of HCII 1-75 greatly reduces the ability of glycosaminoglycans (GAGs) to accelerate the inhibition of thrombin, and...

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Detalhes bibliográficos
Main Authors: Boyle, Amanda J, Roddick, Leigh Ann, Bhakta, Varsha, Lambourne, Melissa D, Junop, Murray S, Liaw, Patricia C, Weitz, Jeffrey I, Sheffield, William P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601010/
https://ncbi.nlm.nih.gov/pubmed/23496873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-14-6
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