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Has the Time Come for Predictive Computer Modeling in CNS Drug Discovery and Development?
We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might impro...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600733/ https://ncbi.nlm.nih.gov/pubmed/23835798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.17 |
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