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Has the Time Come for Predictive Computer Modeling in CNS Drug Discovery and Development?

We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might impro...

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Detalhes bibliográficos
Main Authors: Geerts, H, Spiros, A, Roberts, P, Carr, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600733/
https://ncbi.nlm.nih.gov/pubmed/23835798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.17
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