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Has the Time Come for Predictive Computer Modeling in CNS Drug Discovery and Development?
We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might impro...
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| Main Authors: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600733/ https://ncbi.nlm.nih.gov/pubmed/23835798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.17 |
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