Nonlinear Population Pharmacokinetics of Sirolimus in Patients With Advanced Cancer

Sirolimus, the prototypical inhibitor of the mammalian target of rapamycin, has substantial antitumor activity. In this study, sirolimus showed nonlinear pharmacokinetic characteristics over a wide dose range (from 1 to 60 mg/week). The objective of this study was to develop a population pharmacokin...

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Hlavní autoři: Wu, K, Cohen, E E W, House, L K, Ramírez, J, Zhang, W, Ratain, M J, Bies, R R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600722/
https://ncbi.nlm.nih.gov/pubmed/23887441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.18
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