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Nonlinear Population Pharmacokinetics of Sirolimus in Patients With Advanced Cancer

Sirolimus, the prototypical inhibitor of the mammalian target of rapamycin, has substantial antitumor activity. In this study, sirolimus showed nonlinear pharmacokinetic characteristics over a wide dose range (from 1 to 60 mg/week). The objective of this study was to develop a population pharmacokin...

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Détails bibliographiques
Auteurs principaux: Wu, K, Cohen, E E W, House, L K, Ramírez, J, Zhang, W, Ratain, M J, Bies, R R
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600722/
https://ncbi.nlm.nih.gov/pubmed/23887441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.18
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