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Nonlinear Population Pharmacokinetics of Sirolimus in Patients With Advanced Cancer
Sirolimus, the prototypical inhibitor of the mammalian target of rapamycin, has substantial antitumor activity. In this study, sirolimus showed nonlinear pharmacokinetic characteristics over a wide dose range (from 1 to 60 mg/week). The objective of this study was to develop a population pharmacokin...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600722/ https://ncbi.nlm.nih.gov/pubmed/23887441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.18 |
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