Nonlinear Population Pharmacokinetics of Sirolimus in Patients With Advanced Cancer

Sirolimus, the prototypical inhibitor of the mammalian target of rapamycin, has substantial antitumor activity. In this study, sirolimus showed nonlinear pharmacokinetic characteristics over a wide dose range (from 1 to 60 mg/week). The objective of this study was to develop a population pharmacokin...

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Bibliografiske detaljer
Main Authors: Wu, K, Cohen, E E W, House, L K, Ramírez, J, Zhang, W, Ratain, M J, Bies, R R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600722/
https://ncbi.nlm.nih.gov/pubmed/23887441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.18
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