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Direct activation of full-length proapoptotic BAK

Proapoptotic B-cell lymphoma 2 (BCL-2) antagonist/killer (BAK) and BCL-2–associated X (BAX) form toxic mitochondrial pores in response to cellular stress. Whereas BAX resides predominantly in the cytosol, BAK is constitutively localized to the outer mitochondrial membrane. Select BCL-2 homology doma...

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Bibliografiske detaljer
Main Authors: Leshchiner, Elizaveta S., Braun, Craig R., Bird, Gregory H., Walensky, Loren D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600461/
https://ncbi.nlm.nih.gov/pubmed/23404709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214313110
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