Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex

Clostridium perfringens iota-toxin (Ia) mono-ADP ribosylates Arg177 of actin, leading to cytoskeletal disorganization and cell death. To fully understand the reaction mechanism of arginine-specific mono-ADP ribosyl transferase, the structure of the toxin-substrate protein complex must be characteriz...

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Hlavní autoři: Tsurumura, Toshiharu, Tsumori, Yayoi, Qiu, Hao, Oda, Masataka, Sakurai, Jun, Nagahama, Masahiro, Tsuge, Hideaki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600452/
https://ncbi.nlm.nih.gov/pubmed/23382240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217227110
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