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Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation
Somatic hypermutation and clonal selection lead to B cells expressing high-affinity antibodies. Here we show that somatic mutations not only play a critical role in antigen binding, they also affect the thermodynamic stability of the antibody molecule. Somatic mutations directly involved in antigen...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600448/ https://ncbi.nlm.nih.gov/pubmed/23440204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301810110 |
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