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Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

Somatic hypermutation and clonal selection lead to B cells expressing high-affinity antibodies. Here we show that somatic mutations not only play a critical role in antigen binding, they also affect the thermodynamic stability of the antibody molecule. Somatic mutations directly involved in antigen...

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Detalles Bibliográficos
Main Authors: Wang, Feng, Sen, Shiladitya, Zhang, Yong, Ahmad, Insha, Zhu, Xueyong, Wilson, Ian A., Smider, Vaughn V., Magliery, Thomas J., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600448/
https://ncbi.nlm.nih.gov/pubmed/23440204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301810110
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