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Hydrogen-Exchange Mass Spectrometry for the Study of Intrinsic Disorder in Proteins

Amide hydrogen/deuterium exchange detected by mass spectrometry (HXMS) is seeing wider use for the identification of intrinsically disordered parts of proteins. In this review, we discuss examples of how discovery of intrinsically disordered regions and their removal can aid in structure determinati...

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Detalhes bibliográficos
Main Authors: Balasubramaniam, Deepa, Komives, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600394/
https://ncbi.nlm.nih.gov/pubmed/23099262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2012.10.009
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