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Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.

Treatment of A431 human epidermoid cells with epidermal growth factor (EGF; 20 nM) results in decreased proliferation. This is associated with blockage of the cells in the S and/or G2 phases of the cell cycle. We found that tyrphostin, a putative tyrosine kinase inhibitor, in the range of 50 to 100...

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Udgivet i:Mol Cell Biol
Principais autores: Faaland, C A, Mermelstein, F H, Hayashi, J, Laskin, J D
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360039/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850101/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.5.2697-2703.1991
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