Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.

Treatment of A431 human epidermoid cells with epidermal growth factor (EGF; 20 nM) results in decreased proliferation. This is associated with blockage of the cells in the S and/or G2 phases of the cell cycle. We found that tyrphostin, a putative tyrosine kinase inhibitor, in the range of 50 to 100...

Full description

Saved in:
Bibliographic Details
Main Authors: Faaland, C A, Mermelstein, F H, Hayashi, J, Laskin, J D
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC360039/
https://ncbi.nlm.nih.gov/pubmed/1850101
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items