Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.

Treatment of A431 human epidermoid cells with epidermal growth factor (EGF; 20 nM) results in decreased proliferation. This is associated with blockage of the cells in the S and/or G2 phases of the cell cycle. We found that tyrphostin, a putative tyrosine kinase inhibitor, in the range of 50 to 100...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Faaland, C A, Mermelstein, F H, Hayashi, J, Laskin, J D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360039/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850101/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.5.2697-2703.1991
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