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New Betulinic Acid Derivatives for Bevirimat-Resistant Human Immunodeficiency Virus Type-1

Bevirimat (1, BVM) is an anti-HIV agent that blocks HIV-1 replication by interfering with HIV-1 Gag-SP1 processing at a late stage of viral maturation. However, clinical trials of 1 have revealed a high baseline drug resistance that is attributed to naturally-occurring polymorphisms in HIV-1 Gag. To...

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Detalhes bibliográficos
Main Authors: Dang, Zhao, Ho, Phong, Zhu, Lei, Qian, Keduo, Lee, Kuo-Hsiung, Huang, Li, Chen, Chin-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600082/
https://ncbi.nlm.nih.gov/pubmed/23379607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3016969
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