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New Betulinic Acid Derivatives for Bevirimat-Resistant Human Immunodeficiency Virus Type-1
Bevirimat (1, BVM) is an anti-HIV agent that blocks HIV-1 replication by interfering with HIV-1 Gag-SP1 processing at a late stage of viral maturation. However, clinical trials of 1 have revealed a high baseline drug resistance that is attributed to naturally-occurring polymorphisms in HIV-1 Gag. To...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600082/ https://ncbi.nlm.nih.gov/pubmed/23379607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3016969 |
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