High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate

BACKGROUND: Dysfunctional high-density lipoprotein (HDL) may have pro-inflammatory effects on the endothelial cells,which causes atherosclerosis in type 2 diabetes mellitus (T2DM). HDL is a major carrier of sphingosine-1-phosphate (S1P) in plasma while S1P exhibits multiple biological activities. Ho...

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Bibliographic Details
Main Authors: Tong, Xunliang, Peng, Hui, Liu, Donghui, Ji, Liang, Niu, Chenguang, Ren, Jun, Pan, Bing, Hu, Jianying, Zheng, Lemin, Huang, Yining
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599898/
https://ncbi.nlm.nih.gov/pubmed/23360427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-27
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