Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

BACKGROUND: Sphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and vascular tone. Serum S1P is progressively reduced in sepsis patients with increasing severity. S1P function depends on binding t...

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Detalhes bibliográficos
Publicado no:J Intensive Care
Main Authors: Winkler, Martin Sebastian, Märtz, Konstantin B., Nierhaus, Axel, Daum, Günter, Schwedhelm, Edzard, Kluge, Stefan, Gräler, Markus H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472014/
https://ncbi.nlm.nih.gov/pubmed/31019718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40560-019-0376-2
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