Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts.

Xeroderma pigmentosum (XP) variant patients are genetically predisposed to sunlight-induced skin cancer. Fibroblasts derived from these patients are extremely sensitive to the mutagenic effect of UV radiation and are abnormally slow in replicating DNA containing UV-induced photoproducts. However, un...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Wang, Y C, Maher, V M, Mitchell, D L, McCormick, J J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359977/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8321229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.7.4276-4283.1993
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