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Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakarensis in detergents and its ability to degrade the abnormal prion protein

BACKGROUND: Tk-SP is a member of subtilisin-like serine proteases from a hyperthermophilic archaeon Thermococcus kodakarensis. It has been known that the hyper-stable protease, Tk-SP, could exhibit enzymatic activity even at high temperature and in the presence of chemical denaturants. In this work,...

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Bibliographische Detailangaben
Hauptverfasser: Hirata, Azumi, Hori, Yuki, Koga, Yuichi, Okada, Jun, Sakudo, Akikazu, Ikuta, Kazuyoshi, Kanaya, Shigenori, Takano, Kazufumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599501/
https://ncbi.nlm.nih.gov/pubmed/23448268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-13-19
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