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The 3.5 ångström X−ray structure of the human connexin26 gap junction channel is unlikely that of a fully open channel

The permeability of gap junction channels to metabolites, and not simply to small inorganic ions, is likely to play an important role in development, physiology as well as in etiology of several diseases. Here, we combined dual patch clamp and fluorescence imaging techniques with molecular dynamics...

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Bibliografiske detaljer
Main Authors: Zonta, Francesco, Polles, Guido, Sanasi, Maria Federica, Bortolozzi, Mario, Mammano, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599431/
https://ncbi.nlm.nih.gov/pubmed/23445664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-15
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