Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer

BACKGROUND: Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapidly. However, the mechanism regulating PARP1 expression remains unknown. Altera...

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Autores principales: Bi, Fang-Fang, Li, Da, Yang, Qing
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599366/
https://ncbi.nlm.nih.gov/pubmed/23442605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-90
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