Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

BACKGROUND: The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy. METHODS: The safety, tol...

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Main Authors: Cahn, Anthony, Hodgson, Simon, Wilson, Robert, Robertson, Jonathan, Watson, Joanna, Beerahee, Misba, Hughes, Steve C, Young, Graeme, Graves, Rebecca, Hall, David, van Marle, Sjoerd, Solari, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599276/
https://ncbi.nlm.nih.gov/pubmed/23448278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-14-14
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